Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas

Publication/Creation Date
June 9 2015
Lauren M Huyett (creator)
Eyal Dassau (creator)
Howard C Zisser (creator)
Francis J Doyle (creator)
University Of California Santa Barbara (contributor)
Media Type
Journal Article
Persuasive Intent
Treatment of type 1 diabetes mellitus could be greatly improved by applying a closed-loop control strategy to insulin delivery, also known as an artificial pancreas (AP). In this work, we outline the design of a fully implantable AP using intraperitoneal (IP) insulin delivery and glucose sensing. The design process utilizes the rapid glucose sensing and insulin action offered by the IP space to tune a PID controller with insulin feedback to provide safe and effective insulin delivery. The controller was tuned to meet robust performance and stability specifications. An anti-reset windup strategy was introduced to prevent dangerous undershoot toward hypoglycemia after a large meal disturbance. The final controller design achieved 78% of time within the tight glycemic range of 80−140 mg/dL, with no time spent in hypoglycemia. The next step is to test this controller design in an animal model to evaluate the in vivo performance.
HCI Platform
Discursive Type
Location on Body
Living, Treating
Technology Keywords
Artificial Pancreas

Date archived
April 24 2016
Last edited
November 26 2018
How to cite this entry
Lauren M Huyett, Eyal Dassau, Howard C Zisser, Francis J Doyle. (June 9 2015). "Design and Evaluation of a Robust PID Controller for a Fully Implantable Artificial Pancreas". Industrial & Engineering Chemistry Research. Fabric of Digital Life.