Orally ingestible medical devices for gut engineering
Publication/Creation DateMay 13 2020
Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro- to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials–device design–pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.
Date archivedOctober 4 2021
Last editedOctober 4 2021
How to cite this entry
Nikolaj Kofoed Mandsberg, Juliane Fjelrad Christfort, Khorshid Kamguyan, Anja Boisen, Sarvesh Kumar Srivastava. (May 13 2020). "Orally ingestible medical devices for gut engineering". Advanced Drug Delivery Reviews. Fabric of Digital Life. https://fabricofdigitallife.com/Detail/objects/5471